Trained under the guidance of Maria Tipo, Andrea Lucchesini garnered international recognition at a very young age when he won the "Dino Ciani" International Competition at the Teatro alla Scala in Milan. Since then he has performed throughout the world with leading orchestras, working with conductors such as Claudio Abbado, Semyon Bychkov, Roberto Abbado, Riccardo Chailly, Dennis Russell Davies, Charles Dutoit, Daniele Gatti, Gabriele Ferro,Franz Welser Moest, Daniel Harding, Vladimir Jurowski, Gianandrea Noseda and Giuseppe Sinopoli.

His wide-ranging activities, marked by a desire to explore music with no limitations, lead him to offer programs ranging from classical to current repertoire. In 1994 this earned him the recognition of European musicologists from which he received the Accademia Chigiana International Prize (the only Italian honoured so far). The following year he won the F. Abbiati Prize, which confirmed the appreciation of the Italian critics.

Lucchesini has made several recordings, the first few of which date back to the 1980s for EMI International (Liszt's Sonata in B minor, Beethoven's Sonata op.106 Hammerklavierand Chopin’s Sonata op.58). He then recorded Schoenberg’s Pierrot Lunaire and Berg's Chamber Concerto for Teldec with the Dresden Staatskapelle conducted by Giuseppe Sinopoli.

For BMG the pianist recorded Luciano Berio’s Concerto Echoing Curves, conducted by the composer himself. This marked one of the milestones of a close collaboration with Berio, with whom Lucchesini witnessed the creation of the composer’s final and challenging work for solo piano, Sonata. Lucchesini performed the world premiere of this piece in 2001 which - together with all of Berio’s other piano works - became part of a CD for AVIE Records, which met with unanimous international critical acclaim. 
Equally appreciated is Lucchesini’s live recording of Beethoven’s complete cycle 32 sonatas for Stradivarius. The collective work obtained the recognition of "CD of the month" by the prestigious German magazine “Fonoforum” in August, 2004.

In recent years, Lucchesini has enthusiastically immersed himself in the Schubertian repertoire, starting with the recording of the improvisers, in an AVIE Records CD accepted by the applause of international critics;

In 2018 the German label AUDITE  releases the new recording of Andrea Lucchesini: Dialogues, with music of Scarlatti/Berio, Schubert/Widmann: different musical eras face one another in a dialogue which rises more affinities than ever thought.

In Fall 2018 Lucchesini will present partially this program in New York and in Vancouver

Since 1990, the pianist has dedicated his attention to chamber music as well, including in particular a close collaboration (performing and recording) with cellist Mario Brunello and Quartetto di Cremona, and exploring various formations in chamber music repertoire. 

Convinced that imparting musical knowledge to the younger generations is a moral duty, Lucchesini is passionately dedicated to teaching. He currently teaches at the Scuola di Musica di Fiesole, where he has been artistic director from 2008 till 2016. He is frequently invited to hold masterclasses at major music institutions in Europe, such as the Musik Hochschule in Hannover and the Sommer Wasserbuger Festspiele and Musik Hochschule in Salzburg and in New York.

He serves on juries at numerous piano competitions all over the world and was named Accademico of Santa Cecilia in 2008.